Dried and powdered
Glycosides, steroids, carbohydrates, saponins, and tannins
Calm & Cooling ... Cucumber Peel extract makes a wonderful addition to skin care product for its anti-inflammatory and skin tightening properties! It is greenish brown in color with a faintly woody scent. Cucumber is rich in vitamins, minerals and enzymes essential for strong cell growth and repair. In addition, cucumber peel offers a natural source for a fresh, powerful antioxidant.
Cucumber Peel Extract can be used to keep the facial skin soft while providing a natural sunscreen. It also acts as a skin toner and can be used in astringent. Revitalize stressed and tired skin, leaving calm, cool and radiant.
Free Radical Scavenging and Analgesic Activities of Cucumis sativus L. Fruit Extract
The aqueous fruit extract of Cucumis sativus L. was screened for free radical scavenging and analgesic activities. The extract was subjected to in vitro antioxidant studies at 250 and 500 μg/ml and analgesic study at the doses 250 and 500 mg/kg, respectively. The free radical scavenging was compared with ascorbic acid, BHA (Butylated hydroxyl anisole), whereas, the analgesic effect was compared with Diclofenac sodium (50 mg/kg). The C. sativusfruit extract showed maximum antioxidant and analgesic effect at 500 μg/ml and 500 mg/kg, respectively. The presence of flavonoids and tannins in the extract as evidenced by preliminary phytochemical screening suggests that these compounds might be responsible for free radical scavenging and analgesic effects.
RESULTS AND DISCUSSION
The aqueous extract of C. sativus fruit was screened for various chemical
tests as per the reported methods and was found to contain glycosides,
steroids, flavonoids, carbohydrates, terpenoids, and tannins. The free radical
scavenging effects of C. sativus was evaluated by various in vitro methods.
The DPPH radicals were used as a substrate to evaluate the free radical
scavenging activities of the fruit extract. It involved the reaction of specific antioxidants with a stable free radical 2, 2-diphenyl-1-picryl-hydrazyl (DPPH*). As a result, there was a reduction of DPPH concentration by the antioxidant, which decreased the optical absorbance of DPPH; this was detected by a spectrophotometer at 517 nm. BHA and ascorbic acid were used as standards. The scavenging effect of the fruit extract of C. sativus on the DPPH radical was 56.15%, at a concentration of 500
μg/ml. These results indicated that the extract had a noticeable effect on
scavenging the free radicals. In the nitric oxide scavenging study, a crude
extract of the fruit was screened for its inhibitory effect on nitric oxide
production and compared with ascorbic acid. The extract showed
inhibition of concentration-dependent nitric oxide production.
The present study indicates that the extract has shown strong analgesic action in mice, by inhibiting the acetic acid-induced writhing and by increasing the latency period in the hot-plate test. These findings seem to, in part, justify the folkloric uses of this plant. Furthermore, it has been reported that phytochemical compounds like flavonoids and tannins, commonly found in plants have multiple biological effects, including antioxidant activity. There are also reports on the role of the flavonoid, a powerful antioxidant, in the analgesic activity, primarily by targeting prostaglandins.Again the plant extract demonstrated good antioxidant action in the tested models. Therefore, it can be assumed that the cyclooxygenase (COX) inhibitory activity together with the antioxidant activity may reduce the production of free arachidonic acid from the phospholipid or may inhibit the enzyme system responsible for the synthesis of prostaglandins and ultimately relieve the sensation of pain. Moreover, the reducing properties are generally associated with the presence of reductones, which have been shown to exert antioxidant action by breaking the free radical chain, by donating a hydrogen atom. Therefore, antioxidants with free radical scavenging activities may have great relevance in the prevention and treatment of diseases associated with oxidants or free radicals.
Upon preliminary phytochemical screening, the aqueous extract of C. sativus fruit was found to contain glycosides, steroids, carbohydrates, saponins, and tannins. Therefore, the presence of flavonoids and tannins in the extract suggests that these compounds might be responsible for free radical scavenging and analgesic effects of the extract. The components responsible for the antioxidative and antinociceptive activities of the fruit extract are currently unclear. Therefore, it is suggested that further studies be performed on the isolation and identification of the pure components of C. sativus fruits.